gfish: (sketch)
gfish ([personal profile] gfish) wrote2016-10-03 12:20 pm

Drug trial

Earlier this year I ran a drug trial on myself, in part to see just how rigorous such a thing could be. Here are the results.

[identity profile] sistawendy.livejournal.com 2016-10-03 07:41 pm (UTC)(link)
The first challenge was to produce treatment and control pills that couldn’t be distinguished from each other, even by the person who had made them.

Bless your demented, geeky little heart. And I wish you significant results next time.

[identity profile] tylik.livejournal.com 2016-10-03 08:32 pm (UTC)(link)
I am as amused as heck.

Spell checking the title may also be in order...

[identity profile] gfish.livejournal.com 2016-10-03 08:41 pm (UTC)(link)
Yeah, it was lovely editing in emacs and using LaTeX again, but I guess I'm more dependent on universal modern spellcheck than I realized. :P

[identity profile] tylik.livejournal.com 2016-10-03 08:42 pm (UTC)(link)
Red squigglies make the world go 'round.

...I use an unholy hybrid.

[identity profile] peteralway.livejournal.com 2016-10-04 01:28 am (UTC)(link)
Considering that I notice "rusty breath" after taking iron supplements, I couldn't do this to myself.

But still I do like actually testing things like this.

[identity profile] bopeepsheep.livejournal.com 2016-10-04 06:20 am (UTC)(link)
Love it. I have been running B12 experiments with myself (indications are that it does help my symptoms, via the "forget to take it, symptoms worsen, remember to take it" route) but it's hard to introduce the control aspect without a third party...
*makes note to discuss experiment protocols with proto-scientist aka 13yo son*
callibr8: icon courtesy of Wyld_Dandelyon (cflute)

[personal profile] callibr8 2016-10-07 11:14 pm (UTC)(link)
TL;DR -- try magnesium supplementation. Details below.

I've been having a muscle spasm problem myself; mine manifests most often on the left inner thigh (adductors, I think?). My ARNP (who practices up in Bothell, and has given me excellent advice over about three years now about ways to combine supplements and Rx meds) suggested that I start taking a magnesium supplement. I chose Natural Calm, which provides 325 mg of magnesium citrate per dose, dissolved in water. I took it in this form (one dose per day) for several months, and it helped some. As fate would have it, when I went to restock they were out of my preferred flavor (cherry), so I looked at tablet options, and decided to try "KAL Triple Source", which delivers 500 mg of magnesium as a combination of magnesium oxide, malate and citrate; along with 5mg of Vitamin B-6 to aid absorption. I noticed that about one week after I'd switched to the tablet form (one tablet per day, with a meal or glass of water), the muscle spasms had dropped down to almost nothing (frequency going from multiple times per day sans supplement to 1-2x per week with tablet supplement, usually when I was somewhat dehydrated). I've stayed with higher dose, multiple-source forms since. When I ran out and didn't restock for several days, the muscle spasms came back, again predominantly in the same location and several times a day. I went back on a daily 1-tablet dose of a different multi-source magnesium supplement (400 mg with 50 mg of B-6) and they dropped off again.

Not sure how useful this information will be, as I take several Rx and supplements daily (details available via private email, on request), but figured it was worth mentioning, since the only thing that did vary over time was the amount and type of magnesium supplementation.