As has lower bond strength so it's likely to be a lot less stable long-term. But beyond that, I'm thinking it'd be very hard to form eukaryotic cells because you need a fairly good match between the host and the proto-mitochondria (I'm making the assumption that mitochondria started as parasites, rather than as ingested-but-not-digested food) for both to survive, so having one chock full of arsenic is going to make matching more difficult. A significant number of people are arguing that the prokaryote-eukaryote transition is more unlikely and difficult than the primordial soup-bacteria transition, leading me to imagine a universe of bacteria-filled planets with very few organized multicellular lifeforms.
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